FBXL14 (F-box and leucine rich repeat protein 14)

2014-08-01  

Identity

HGNC
FBXL14
LOCATION
12p13.33
LOCUSID
144699
ALIAS
Fbl14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 144699
MIM: 609081
HGNC: 28624
Ensembl: ENSG00000171823

Variants:

dbSNP: 144699
ClinVar: 144699
TCGA: ENSG00000171823
COSMIC: FBXL14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171823ENST00000339235Q8N1E6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
342851822021Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization.5
342851822021Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization.5
293481452018FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.13
299736902018FBXL14 abolishes breast cancer progression by targeting CDCP1 for proteasomal degradation.11
293481452018FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.13
299736902018FBXL14 abolishes breast cancer progression by targeting CDCP1 for proteasomal degradation.11
279239072017Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination.80
279239072017Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination.80
199555722010The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation.89
199555722010The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation.89

Citation

Dessen P

FBXL14 (F-box and leucine rich repeat protein 14)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54313/gene-explorer/js/lib/case-report-explorer