FMNL3 (formin like 3)

2014-08-01  

Identity

HGNC
FMNL3
LOCATION
12q13.12
LOCUSID
91010
ALIAS
FHOD3,FRL2,WBP-3,WBP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 91010
MIM: 616288
HGNC: 23698
Ensembl: ENSG00000161791

Variants:

dbSNP: 91010
ClinVar: 91010
TCGA: ENSG00000161791
COSMIC: FMNL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161791ENST00000335154Q8IVF7
ENSG00000161791ENST00000352151Q8IVF7
ENSG00000161791ENST00000550424F8VYL1
ENSG00000161791ENST00000550488F8W1F5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208626872010Assembly of filopodia by the formin FRL2 (FMNL3).37
254289842015The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion.16
222754302012The formin FMNL3 is a cytoskeletal regulator of angiogenesis.15
264468362015Cell type-dependent mechanisms for formin-mediated assembly of filopodia.15
227909472012Protein N-myristoylation is required for cellular morphological changes induced by two formin family proteins, FMNL2 and FMNL3.11
242238032013Metastasis suppressor microRNA-335 targets the formin family of actin nucleators.11
276458942016MicroRNA-127 is a tumor suppressor in human esophageal squamous cell carcinoma through the regulation of oncogene FMNL3.11
262995182015The Formin FMNL3 Controls Early Apical Specification in Endothelial Cells by Regulating the Polarized Trafficking of Podocalyxin.8
257582002015Increased expression of formin-like 3 contributes to metastasis and poor prognosis in colorectal carcinoma.5
302287822018Formin-like 3 regulates RhoC/FAK pathway and actin assembly to promote cell invasion in colorectal carcinoma.3

Citation

Dessen P

FMNL3 (formin like 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54318/fmnl3-(formin-like-3)