GOLGB1 (golgin B1)

2014-08-01  

Identity

HGNC
LOCATION
3q13.33
LOCUSID
ALIAS
GCP,GCP372,GOLIM1
FUSION GENES

Other Information

Locus ID:

NCBI: 2804
MIM: 602500
HGNC: 4429
Ensembl: ENSG00000173230

Variants:

dbSNP: 2804
ClinVar: 2804
TCGA: ENSG00000173230
COSMIC: GOLGB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173230ENST00000340645Q14789
ENSG00000173230ENST00000393667Q14789
ENSG00000173230ENST00000472475C9J8Q0
ENSG00000173230ENST00000482512F8WF12
ENSG00000173230ENST00000489400H0Y867
ENSG00000173230ENST00000491690H7C5I7
ENSG00000173230ENST00000494517E7EU81
ENSG00000173230ENST00000614479Q14789

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
COPI-mediated anterograde transportREACTOMER-HSA-6807878

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124298222002CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin.45
174752462007Giantin interacts with both the small GTPase Rab6 and Rab1.23
250860692014Restoration of compact Golgi morphology in advanced prostate cancer enhances susceptibility to galectin-1-induced apoptosis by modifying mucin O-glycan synthesis.23
240464482013A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2.21
234227532013Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia.18
304535272018Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver Cells.5
266647862015Polymorphisms in three genes are associated with hemorrhagic stroke.2
287826252017Shifted Golgi targeting of glycosyltransferases and α-mannosidase IA from giantin to GM130-GRASP65 results in formation of high mannose N-glycans in aggressive prostate cancer cells.2
235557932013The golgin tether giantin regulates the secretory pathway by controlling stack organization within Golgi apparatus.0
294306282018Association between GOLGB1 tag-polymorphisms and nonsyndromic cleft palate only in the Brazilian population.0

Citation

Dessen P

GOLGB1 (golgin B1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54336/golgb1