KCNN1 (potassium calcium-activated channel subfamily N member 1)

2014-08-01  

Identity

HGNC
KCNN1
LOCATION
19p13.11
LOCUSID
3780
ALIAS
KCa2.1,SK1,SKCA1,hSK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3780
MIM: 602982
HGNC: 6290
Ensembl: ENSG00000105642

Variants:

dbSNP: 3780
ClinVar: 3780
TCGA: ENSG00000105642
COSMIC: KCNN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105642ENST00000222249Q92952
ENSG00000105642ENST00000609922V9GYV2
ENSG00000105642ENST00000615435A0A087X2E7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Insulin secretionKEGGhsa04911
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Ca2+ activated K+ channelsREACTOMER-HSA-1296052

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10832corticosteroidsChemicalVariantAnnotationassociatedPD30697902
PA443450AsthmaDiseaseVariantAnnotationassociatedPD30697902

References

Pubmed IDYearTitleCitations
221549082012Decreased expression of small-conductance Ca2+-activated K+ channels SK1 and SK2 in human chronic atrial fibrillation.20
244345222014Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons.16
297379742018Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca2+-Activated K+ Current in Patients with Chronic Atrial Fibrillation.3
310485492019Preferred Formation of Heteromeric Channels between Coexpressed SK1 and IKCa Channel Subunits Provides a Unique Pharmacological Profile of Ca<sup>2+</sup>-Activated Potassium Channels.1
125987272003Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel.0

Citation

Dessen P

KCNN1 (potassium calcium-activated channel subfamily N member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54397/kcnn1-(potassium-calcium-activated-channel-subfamily-n-member-1)