PLA2G15 (phospholipase A2 group XV)

2014-08-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
ACS,GXVPLA2,LLPL,LPLA2,LYPLA3
FUSION GENES

Other Information

Locus ID:

NCBI: 23659
MIM: 609362
HGNC: 17163
Ensembl: ENSG00000103066

Variants:

dbSNP: 23659
ClinVar: 23659
TCGA: ENSG00000103066
COSMIC: PLA2G15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103066ENST00000219345Q8NCC3
ENSG00000103066ENST00000413021Q8NCC3
ENSG00000103066ENST00000444212B4DPU0
ENSG00000103066ENST00000564827H3BPT3
ENSG00000103066ENST00000565744H3BM47
ENSG00000103066ENST00000566188B4DJW4
ENSG00000103066ENST00000566978H3BT70
ENSG00000103066ENST00000568082H3BMU8

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Glycerophospholipid metabolismKEGGhsa00564
LysosomeKEGGko04142
LysosomeKEGGhsa04142

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
194610402009Lipoprotein-associated phospholipase A2 and C-reactive protein for risk-stratification of patients with TIA.16
189834942009Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study).11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
276622542016Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens.8
147549072004Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells.5
293302842018Novel Intergenically Spliced Chimera, NFATC3-PLA2G15, Is Associated with Aggressive T-ALL Biology and Outcome.2
308307532019Structural Basis of Lysosomal Phospholipase A2 Inhibition by Zn2.0

Citation

Dessen P

PLA2G15 (phospholipase A2 group XV)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54539/pla2g15