SFI1 (SFI1 centrin binding protein)

2014-08-01  

Identity

HGNC
SFI1
LOCATION
22q12.2
LOCUSID
9814
ALIAS
PISD,PPP1R139,hSfi1p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9814
MIM: 612765
HGNC: 29064
Ensembl: ENSG00000198089

Variants:

dbSNP: 9814
ClinVar: 9814
TCGA: ENSG00000198089
COSMIC: SFI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198089ENST00000400288A8K8P3
ENSG00000198089ENST00000400289A8K8P3
ENSG00000198089ENST00000411518F8WBU4
ENSG00000198089ENST00000417682H0Y5I7
ENSG00000198089ENST00000425671H0Y836
ENSG00000198089ENST00000432498A8K8P3
ENSG00000198089ENST00000443011D3YTJ2
ENSG00000198089ENST00000444859X6RJF9
ENSG00000198089ENST00000450787H7BZF3
ENSG00000198089ENST00000452250H7C2F1
ENSG00000198089ENST00000524296E5RJU6
ENSG00000198089ENST00000540643A8K8P3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

References

Pubmed IDYearTitleCitations
361251822022Human SFI1 and Centrin form a complex critical for centriole architecture and ciliogenesis.11
361251822022Human SFI1 and Centrin form a complex critical for centriole architecture and ciliogenesis.11
324285542020Genome-wide investigation of DNA methylation in congenital adrenal hyperplasia.1
324285542020Genome-wide investigation of DNA methylation in congenital adrenal hyperplasia.1
311970302019SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL.10
311970302019SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL.10
269238032016A chirality change in XPC- and Sfi1-derived peptides affects their affinity for centrin.0
269238032016A chirality change in XPC- and Sfi1-derived peptides affects their affinity for centrin.0
198575002010Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex.16
198575002010Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex.16

Citation

Dessen P

SFI1 (SFI1 centrin binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54614/tumors-explorer/favicon/js/lib/jquery-3.5.1.min.js