TAS2R1 (taste 2 receptor member 1)

2014-08-01  

Identity

HGNC
TAS2R1
LOCATION
5p15.31
LOCUSID
50834
ALIAS
T2R1,TRB7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 50834
MIM: 604796
HGNC: 14909
Ensembl: ENSG00000169777

Variants:

dbSNP: 50834
ClinVar: 50834
TCGA: ENSG00000169777
COSMIC: TAS2R1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169777ENST00000382492Q9NYW7
ENSG00000169777ENST00000506620U3KPZ8
ENSG00000169777ENST00000514078U3KQT0

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
359028802022TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment.3
359028802022TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment.3
328761082020The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19.3
328761082020The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19.3
266842512016Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.33
266842512016Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.33
255730832015Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.27
255730832015Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.27
226835712012TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.48
226835712012TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.48
216194502011Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies.6
218522412011Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).24
216194502011Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies.6
218522412011Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).24
205997052010Bitter taste receptor T2R1 is activated by dipeptides and tripeptides.21

Citation

Dessen P

TAS2R1 (taste 2 receptor member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54686/haematological-explorer/js/web-card-gene.js