TDRD3 (tudor domain containing 3)

2014-08-01  

Identity

HGNC
TDRD3
LOCATION
13q21.2
LOCUSID
81550
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81550
MIM: 614392
HGNC: 20612
Ensembl: ENSG00000083544

Variants:

dbSNP: 81550
ClinVar: 81550
TCGA: ENSG00000083544
COSMIC: TDRD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000083544ENST00000196169Q9H7E2
ENSG00000083544ENST00000196169A0A024QZE0
ENSG00000083544ENST00000377881Q9H7E2
ENSG00000083544ENST00000377881A0A024QZE0
ENSG00000083544ENST00000377882B1AMN9
ENSG00000083544ENST00000377894Q9H7E2
ENSG00000083544ENST00000377894A0A024QZE0
ENSG00000083544ENST00000484389F2Z2Y2
ENSG00000083544ENST00000535286Q9H7E2
ENSG00000083544ENST00000621840Q9H7E2
ENSG00000083544ENST00000648252Q9H7E2
ENSG00000083544ENST00000648252A0A024QZE0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
211726652010TDRD3 is an effector molecule for arginine-methylated histone marks.88
186326872008TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.53
186644582008Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP.36
223634332012Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30.23
272570632016RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals.19
281768342017Structural basis of the interaction between Topoisomerase IIIβ and the TDRD3 auxiliary factor.2
296453622018Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit.2
286985902017Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells.1

Citation

Dessen P

TDRD3 (tudor domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54697/tdrd3