TSC22D4 (TSC22 domain family member 4)

2014-08-01  

Identity

HGNC
TSC22D4
LOCATION
7q22.1
LOCUSID
81628
ALIAS
THG-1,THG1,TILZ2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81628
MIM: 611914
HGNC: 21696
Ensembl: ENSG00000166925

Variants:

dbSNP: 81628
ClinVar: 81628
TCGA: ENSG00000166925
COSMIC: TSC22D4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166925ENST00000300181Q9Y3Q8
ENSG00000166925ENST00000393991Q9Y3Q8
ENSG00000166925ENST00000423266H7BZ77
ENSG00000166925ENST00000456330H7C0M8

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376077792023Promotion of squamous cell carcinoma tumorigenesis by oncogene-mediated THG-1/TSC22D4 phosphorylation.2
376077792023Promotion of squamous cell carcinoma tumorigenesis by oncogene-mediated THG-1/TSC22D4 phosphorylation.2
353783292022Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function.3
357145702022TSC22D4 promotes TGFβ1-induced activation of hepatic stellate cells.2
353783292022Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function.3
357145702022TSC22D4 promotes TGFβ1-induced activation of hepatic stellate cells.2
318063662020Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB.3
318647042020THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells.3
318063662020Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB.3
318647042020THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells.3
278273632016Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.13
278273632016Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.13
201492642010Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila.11
210599362010tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases.38
201492642010Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila.11

Citation

Dessen P

TSC22D4 (TSC22 domain family member 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54727/js/lib/popper.js