USP37 (ubiquitin specific peptidase 37)

2014-08-01  

Identity

HGNC
USP37
LOCATION
2q35
LOCUSID
57695
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57695
HGNC: 20063
Ensembl: ENSG00000135913

Variants:

dbSNP: 57695
ClinVar: 57695
TCGA: ENSG00000135913
COSMIC: USP37

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135913ENST00000258399Q86T82
ENSG00000135913ENST00000338465Q86W68
ENSG00000135913ENST00000415516Q86T82
ENSG00000135913ENST00000418019Q86T82
ENSG00000135913ENST00000454775Q86T82

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
215963152011Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.66
252845842015USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer.33
230278772012Skp1-Cul1-F-box ubiquitin ligase (SCF(βTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry.16
232085072013The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability.14
226650642013The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation.12
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
262995172015The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.10
272968722016USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication.10
284839472017Regulation of USP37 Expression by REST-Associated G9a-Dependent Histone Methylation.10
243242622014Ubiquitin-interacting motifs confer full catalytic activity, but not ubiquitin chain substrate specificity, to deubiquitinating enzyme USP37.8

Citation

Dessen P

USP37 (ubiquitin specific peptidase 37)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54761/usp37-(ubiquitin-specific-peptidase-37)