VAMP8 (vesicle associated membrane protein 8)

2014-08-01  

Identity

HGNC
VAMP8
LOCATION
2p11.2
LOCUSID
8673
ALIAS
EDB,VAMP-8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8673
MIM: 603177
HGNC: 12647
Ensembl: ENSG00000118640

Variants:

dbSNP: 8673
ClinVar: 8673
TCGA: ENSG00000118640
COSMIC: VAMP8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118640ENST00000263864Q9BV40
ENSG00000118640ENST00000409760B8ZZT4
ENSG00000118640ENST00000432071C9JXZ5

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
Autophagy - animalKEGGko04140
SNARE interactions in vesicular transportKEGGhsa04130
Autophagy - animalKEGGhsa04140
Platelet activationKEGGhsa04611
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Lysosome Vesicle BiogenesisREACTOMER-HSA-432720
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381828882024The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.3
387201362024Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway.0
381828882024The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.3
387201362024Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway.0
374059572023VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma.1
374059572023VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma.1
347528452022Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy.7
363284962022Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8.0
347528452022Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy.7
363284962022Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8.0
340421622021Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway.4
346457992021Prefused lysosomes cluster on autophagosomes regulated by VAMP8.20
347856502021mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation.22
340421622021Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway.4
346457992021Prefused lysosomes cluster on autophagosomes regulated by VAMP8.20

Citation

Dessen P

VAMP8 (vesicle associated membrane protein 8)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54765/haematological-explorer/js/web-card-_common.js