VAPA (VAMP associated protein A)

2014-08-01  

Identity

HGNC
VAPA
LOCATION
18p11.22
LOCUSID
9218
ALIAS
VAMP-A,VAP-33,VAP-A,VAP33,hVAP-33
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9218
MIM: 605703
HGNC: 12648
Ensembl: ENSG00000101558

Variants:

dbSNP: 9218
ClinVar: 9218
TCGA: ENSG00000101558
COSMIC: VAPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101558ENST00000340541Q9P0L0
ENSG00000101558ENST00000400000Q9P0L0
ENSG00000101558ENST00000585042J3QKM9

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379266972024Analysis of small EV proteomes reveals unique functional protein networks regulated by VAP-A.0
379266972024Analysis of small EV proteomes reveals unique functional protein networks regulated by VAP-A.0
366933192023VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites.11
366933192023VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites.11
336197962021CircVAPA exerts oncogenic property in non-small cell lung cancer by the miR-876-5p/WNT5A axis.7
342007282021Role of Vesicle-Associated Membrane Protein-Associated Proteins (VAP) A and VAPB in Nuclear Egress of the Alphaherpesvirus Pseudorabies Virus.1
343128462021Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR.2
336197962021CircVAPA exerts oncogenic property in non-small cell lung cancer by the miR-876-5p/WNT5A axis.7
342007282021Role of Vesicle-Associated Membrane Protein-Associated Proteins (VAP) A and VAPB in Nuclear Egress of the Alphaherpesvirus Pseudorabies Virus.1
343128462021Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR.2
325255832020CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy.62
325255832020CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy.62
307416202019VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway.28
307971482019Circular RNA circVAPA is up-regulated and exerts oncogenic properties by sponging miR-101 in colorectal cancer.62
307416202019VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway.28

Citation

Dessen P

VAPA (VAMP associated protein A)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54766/deep-insight-explorer/gene-explorer/css/lib/bootstrap.min.css