IFNLR1 (interferon lambda receptor 1)

2014-09-01 Affiliation

Identity

HGNC

IFNLR1

LOCATION

1p36.11

LOCUSID

163702

ALIAS

CRF2/12,IFNLR,IL-28R1,IL28RA,LICR2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 163702
MIM: 607404
HGNC: 18584
Ensembl: ENSG00000185436

Variants:

dbSNP: 163702
ClinVar: 163702
TCGA: ENSG00000185436
COSMIC: IFNLR1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000185436	ENST00000327535	Q8IU57
ENSG00000185436	ENST00000327575	Q8IU57
ENSG00000185436	ENST00000374418	Q8IU57
ENSG00000185436	ENST00000374419	Q5VTX9
ENSG00000185436	ENST00000374421	Q8IU57

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Jak-STAT signaling pathway	KEGG	ko04630
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Jak-STAT signaling pathway	KEGG	hsa04630
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12483210	2003	IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.	581
12469119	2003	IL-28, IL-29 and their class II cytokine receptor IL-28R.	481
20953190	2010	A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.	309
15166220	2004	Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling.	110
19798076	2009	Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines.	83
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	75
22891284	2012	Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells.	63
20934432	2010	Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1.	31
19724244	2009	Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.	28
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27

Citation

Dessen P

IFNLR1 (interferon lambda receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54864/ifnlr1