SEC11A (SEC11 homolog A, signal peptidase complex subunit)

2014-09-01  

Identity

HGNC
SEC11A
LOCATION
15q25.2
LOCUSID
23478
ALIAS
1810012E07Rik,SEC11L1,SPC18,SPCS4A,sid2895
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23478
MIM: 618258
HGNC: 17718
Ensembl: ENSG00000140612

Variants:

dbSNP: 23478
ClinVar: 23478
TCGA: ENSG00000140612
COSMIC: SEC11A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140612ENST00000268220P67812
ENSG00000140612ENST00000268220A0A024RC78
ENSG00000140612ENST00000455959P67812
ENSG00000140612ENST00000558134P67812
ENSG00000140612ENST00000558196H0YNX5
ENSG00000140612ENST00000558217H0YNA5
ENSG00000140612ENST00000559729H0YKT4
ENSG00000140612ENST00000560266P67812
ENSG00000140612ENST00000560409H0YNG3

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Protein exportKEGGhsa03060
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Peptide hormone metabolismREACTOMER-HSA-2980736
Synthesis, secretion, and deacylation of GhrelinREACTOMER-HSA-422085
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)REACTOMER-HSA-400511
Gene ExpressionREACTOMER-HSA-74160

References

Pubmed IDYearTitleCitations
368727712023CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs).1
368727712023CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs).1
336751292022MiR-873-5p modulates progression of tongue squamous cell carcinoma via targeting SEC11A.4
364561662022Clinical Significance of SEC11A Expression in Patients With Locally Advanced Gastric Cancer.0
336751292022MiR-873-5p modulates progression of tongue squamous cell carcinoma via targeting SEC11A.4
364561662022Clinical Significance of SEC11A Expression in Patients With Locally Advanced Gastric Cancer.0
343883692021Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.32
343883692021Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.32
320543322020Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis.18
325640262020SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma.2
320543322020Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis.18
325640262020SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma.2
311634192019SEC11A Expression Is Associated with Basal-Like Bladder Cancer and Predicts Patient Survival.4
311634192019SEC11A Expression Is Associated with Basal-Like Bladder Cancer and Predicts Patient Survival.4
278599492017Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression.8

Citation

Dessen P

SEC11A (SEC11 homolog A, signal peptidase complex subunit)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54865/js/lib/bootstrap.min.js