PTGDR2 (prostaglandin D2 receptor 2)

2014-09-01  

Identity

HGNC
PTGDR2
LOCATION
11q12.2
LOCUSID
11251
ALIAS
CD294,CRTH2,DL1R,DP2,GPR44

Other Information

Locus ID:

NCBI: 11251
MIM: 604837
HGNC: 4502
Ensembl: ENSG00000183134

Variants:

dbSNP: 11251
ClinVar: 11251
TCGA: ENSG00000183134
COSMIC: PTGDR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183134ENST00000332539Q9Y5Y4

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Prostanoid ligand receptorsREACTOMER-HSA-391908
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375261902024PGD2/PTGDR2 Signal Affects the Viability, Invasion, Apoptosis, and Stemness of Gastric Cancer Stem Cells and Prevents the Progression of Gastric Cancer.1
375261902024PGD2/PTGDR2 Signal Affects the Viability, Invasion, Apoptosis, and Stemness of Gastric Cancer Stem Cells and Prevents the Progression of Gastric Cancer.1
347504922022High PGD(2) receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model.6
347504922022High PGD(2) receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model.6
343411042021Molecular basis for lipid recognition by the prostaglandin D(2) receptor CRTH2.8
343411042021Molecular basis for lipid recognition by the prostaglandin D(2) receptor CRTH2.8
328515672020YAP promotes self-renewal of gastric cancer cells by inhibiting expression of L-PTGDS and PTGDR2.6
329416182020A Granulocytic Signature Identifies COVID-19 and Its Severity.62
328515672020YAP promotes self-renewal of gastric cancer cells by inhibiting expression of L-PTGDS and PTGDR2.6
329416182020A Granulocytic Signature Identifies COVID-19 and Its Severity.62
307300822019Prostaglandins in androgenetic alopecia in 12 men and four female.5
308254552019Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression.4
307300822019Prostaglandins in androgenetic alopecia in 12 men and four female.5
308254552019Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression.4
292680082018The 3D Structure of Human DP Prostaglandin G-Protein-Coupled Receptor Bound to Cyclopentanoindole Antagonist, Predicted Using the DuplexBiHelix Modification of the GEnSeMBLE Method.4

Citation

Dessen P

PTGDR2 (prostaglandin D2 receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54870/gene-explorer/css/card-gene.css