MAP1LC3C (microtubule associated protein 1 light chain 3 gamma)

2015-02-01  

Identity

HGNC
MAP1LC3C
LOCATION
1q43
LOCUSID
440738
ALIAS
ATG8J,LC3C

Other Information

Locus ID:

NCBI: 440738
MIM: 609605
HGNC: 13353
Ensembl: ENSG00000197769

Variants:

dbSNP: 440738
ClinVar: 440738
TCGA: ENSG00000197769
COSMIC: MAP1LC3C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197769ENST00000357246Q9BXW4

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

References

Pubmed IDYearTitleCitations
370035032023Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells.1
371558542023ATG5 selectively engages virus-tethered BST2/tetherin in an LC3C-associated pathway.2
370035032023Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells.1
371558542023ATG5 selectively engages virus-tethered BST2/tetherin in an LC3C-associated pathway.2
353253422022PGM5P3-AS1 regulates MAP1LC3C to promote cell ferroptosis and thus inhibiting the malignant progression of triple-negative breast cancer.3
353253422022PGM5P3-AS1 regulates MAP1LC3C to promote cell ferroptosis and thus inhibiting the malignant progression of triple-negative breast cancer.3
332308012021Autophagy-Related Protein MAP1LC3C Plays a Crucial Role in Odontogenic Differentiation of Human Dental Pulp Cells.5
339322382021TFG binds LC3C to regulate ULK1 localization and autophagosome formation.11
339886802021Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide.4
332308012021Autophagy-Related Protein MAP1LC3C Plays a Crucial Role in Odontogenic Differentiation of Human Dental Pulp Cells.5
339322382021TFG binds LC3C to regulate ULK1 localization and autophagosome formation.11
339886802021Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide.4
320650212020LC3C mediates selective autophagy of the MET RTK, inhibiting cancer cell invasion.13
325329702020TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes.20
330810142020Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C.16

Citation

Dessen P

MAP1LC3C (microtubule associated protein 1 light chain 3 gamma)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54959/case-report-explorer/css/template-card.css