FKBP6 (FKBP prolyl isomerase family member 6 (inactive))

2015-02-01 Affiliation

Identity

HGNC

FKBP6

LOCATION

7q11.23

LOCUSID

8468

ALIAS

FKBP36

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8468
MIM: 604839
HGNC: 3722
Ensembl: ENSG00000077800

Variants:

dbSNP: 8468
ClinVar: 8468
TCGA: ENSG00000077800
COSMIC: FKBP6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000077800	ENST00000252037	O75344
ENSG00000077800	ENST00000413573	O75344
ENSG00000077800	ENST00000429879	F8WD36
ENSG00000077800	ENST00000431982	O75344
ENSG00000077800	ENST00000442793	C9JM01
ENSG00000077800	ENST00000445032	F8WD38
ENSG00000077800	ENST00000648538	A0A3B3IST2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Gene Silencing by RNA	REACTOME	R-HSA-211000
PIWI-interacting RNA (piRNA) biogenesis	REACTOME	R-HSA-5601884
Cell Cycle	REACTOME	R-HSA-1640170
Meiosis	REACTOME	R-HSA-1500620
Meiotic synapsis	REACTOME	R-HSA-1221632

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36150389	2022	The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.	4
36150389	2022	The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.	4
24241165	2014	Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population.	12
24241165	2014	Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population.	12
20378615	2010	Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.	61
20378615	2010	Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.	61
19001379	2009	FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor.	9
19001379	2009	FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor.	9
18529014	2008	FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes.	6
18529014	2008	FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes.	6
17307919	2007	Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men.	16
17307919	2007	Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men.	16
17307919	2007	Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men.	16
17307919	2007	Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men.	16
15696470	2005	[Possible association between 278C/A single nucleotide polymorphism of FKBP6 and idiopathic azoospermia].	1

Citation

Dessen P

FKBP6 (FKBP prolyl isomerase family member 6 (inactive))

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54970/js/css/template-nav.css