MPC2 (mitochondrial pyruvate carrier 2)

2015-03-01  

Identity

HGNC
MPC2
LOCATION
1q24.2
LOCUSID
25874
ALIAS
BRP44,SLC54A2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25874
MIM: 614737
HGNC: 24515
Ensembl: ENSG00000143158

Variants:

dbSNP: 25874
ClinVar: 25874
TCGA: ENSG00000143158
COSMIC: MPC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143158ENST00000271373O95563
ENSG00000143158ENST00000271373A0A024R8Z5
ENSG00000143158ENST00000367846O95563
ENSG00000143158ENST00000367846A0A024R8Z5
ENSG00000143158ENST00000458574Q5R3B4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364171802023MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy.2
364171802023MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy.2
337913912021Decreased Expression of MPC2 Contributes to Aerobic Glycolysis and Colorectal Cancer Proliferation by Activating mTOR Pathway.5
346649672021Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes.6
337913912021Decreased Expression of MPC2 Contributes to Aerobic Glycolysis and Colorectal Cancer Proliferation by Activating mTOR Pathway.5
346649672021Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes.6
324034312020Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases.12
326648962020Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy.4
327089192020The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier.38
324034312020Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases.12
326648962020Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy.4
327089192020The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier.38
294725612018Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter.26
298451982018Hypoxia induces lactate secretion and glycolytic efflux by downregulating mitochondrial pyruvate carrier levels in human umbilical vein endothelial cells.12
300873172018Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations.3

Citation

Dessen P

MPC2 (mitochondrial pyruvate carrier 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55100/gene-fusions/favicon/js/web-card-gene.js