TRIOBP (TRIO and F-actin binding protein)

2015-03-01  

Identity

HGNC
TRIOBP
LOCATION
22q13.1
LOCUSID
11078
ALIAS
DFNB28,HRIHFB2122,TAP68,TARA,dJ37E16.4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11078
MIM: 609761
HGNC: 17009
Ensembl: ENSG00000100106

Variants:

dbSNP: 11078
ClinVar: 11078
TCGA: ENSG00000100106
COSMIC: TRIOBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100106ENST00000344404H7BXW4
ENSG00000100106ENST00000403663Q9H2D6
ENSG00000100106ENST00000407319Q9H2D6
ENSG00000100106ENST00000413051H0Y5T8
ENSG00000100106ENST00000417857F6WYE2
ENSG00000100106ENST00000418339F6TR96
ENSG00000100106ENST00000428075H0Y5J9
ENSG00000100106ENST00000452519F6WMF4
ENSG00000100106ENST00000644935Q9H2D6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374803052023SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED FOLLOW UP STUDY.0
381570202023TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis.0
374803052023SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED FOLLOW UP STUDY.0
381570202023TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis.0
360291642022Elucidation of repeat motifs R1- and R2-related TRIOBP variants in autosomal recessive nonsyndromic hearing loss DFNB28 among indigenous South African individuals.2
362323512022TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein.1
360291642022Elucidation of repeat motifs R1- and R2-related TRIOBP variants in autosomal recessive nonsyndromic hearing loss DFNB28 among indigenous South African individuals.2
362323512022TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein.1
295071112018Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG proteins in the heart.7
298909892018Emerging roles of TRIO and F-actin-binding protein in human diseases.6
295071112018Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG proteins in the heart.7
298909892018Emerging roles of TRIO and F-actin-binding protein in human diseases.6
280897342017Broadening the phenotype of DFNB28: Mutations in TRIOBP are associated with moderate, stable hereditary hearing impairment.15
284388372017An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure.14
291973522017Whole exome sequencing identifies TRIOBP pathogenic variants as a cause of post-lingual bilateral moderate-to-severe sensorineural hearing loss.11

Citation

Dessen P

TRIOBP (TRIO and F-actin binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55136/meetings/js/lib/favicon/favicon-16x16.png