USP45 (ubiquitin specific peptidase 45)

2015-04-01  

Identity

HGNC
LOCATION
6q16.2
LOCUSID
ALIAS
LCA19
FUSION GENES

Other Information

Locus ID:

NCBI: 85015
MIM: 618439
HGNC: 20080
Ensembl: ENSG00000123552

Variants:

dbSNP: 85015
ClinVar: 85015
TCGA: ENSG00000123552
COSMIC: USP45

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123552ENST00000327681Q70EL2
ENSG00000123552ENST00000329966D6RBV3
ENSG00000123552ENST00000369233E2QRF0
ENSG00000123552ENST00000472914D6RBV3
ENSG00000123552ENST00000496090H0Y8Q0
ENSG00000123552ENST00000496518H0Y8J5
ENSG00000123552ENST00000500704Q70EL2
ENSG00000123552ENST00000506871D6RC01
ENSG00000123552ENST00000507717H0YA21
ENSG00000123552ENST00000508908D6RE98
ENSG00000123552ENST00000511403H0Y986

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369296332023MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance.5
369296332023MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance.5
305735632019Biallelic mutations in USP45, encoding a deubiquitinating enzyme, are associated with Leber congenital amaurosis.11
305735632019Biallelic mutations in USP45, encoding a deubiquitinating enzyme, are associated with Leber congenital amaurosis.11
302581002018USP45 and Spindly are part of the same complex implicated in cell migration.7
302581002018USP45 and Spindly are part of the same complex implicated in cell migration.7
255382202015USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses.35
255382202015USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses.35

Citation

Dessen P

USP45 (ubiquitin specific peptidase 45)

Atlas Genet Cytogenet Oncol Haematol. 2015-04-01

Online version: http://atlasgeneticsoncology.org/gene/55158/css/lib/js/template.js