ADRA2A (adrenoceptor alpha 2A)

2015-05-01  

Identity

HGNC
ADRA2A
LOCATION
10q25.2
LOCUSID
150
ALIAS
ADRA2,ADRA2R,ADRAR,ALPHA2AAR,ZNF32

Other Information

Locus ID:

NCBI: 150
MIM: 104210
HGNC: 281
Ensembl: ENSG00000150594

Variants:

dbSNP: 150
ClinVar: 150
TCGA: ENSG00000150594
COSMIC: ADRA2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150594ENST00000280155P08913

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Metabolism of proteinsREACTOMER-HSA-392499
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Platelet Aggregation (Plug Formation)REACTOMER-HSA-76009
Adrenaline signalling through Alpha-2 adrenergic receptorREACTOMER-HSA-392023
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
AdrenoceptorsREACTOMER-HSA-390696
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (z) signalling eventsREACTOMER-HSA-418597
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Adrenaline,noradrenaline inhibits insulin secretionREACTOMER-HSA-400042
Surfactant metabolismREACTOMER-HSA-5683826

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713257Selective serotonin reuptake inhibitorsChemicalClinicalAnnotationassociatedPD25642918
PA164752812milnacipranChemicalClinicalAnnotationassociatedPD
PA445208PainDiseaseVariantAnnotationnot associatedPD21398039
PA445210Pain, PostoperativeDiseaseClinicalAnnotationassociatedPD
PA446479Hypertrophy, Left VentricularDiseaseClinicalAnnotationassociatedPD15614026
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotation, VariantAnnotationambiguousPD17283289, 18200436, 19150055, 21103886, 23609393, 29230023
PA447207Depressive DisorderDiseaseClinicalAnnotationassociatedPD
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD25642918
PA448499atenololChemicalClinicalAnnotationassociatedPD15614026
PA448665brimonidineChemicalPathwayassociated
PA449051clonidineChemicalPathwayassociated
PA449256dexmedetomidineChemicalClinicalAnnotationassociatedPD21104443
PA449396dopamineChemicalPathwayassociated
PA449470epinephrineChemicalPathwayassociated
PA450121isoproterenolChemicalPathwayassociated
PA450464methylphenidateChemicalClinicalAnnotation, VariantAnnotationambiguousPD17283289, 18200436, 19150055, 21103886, 23609393, 29230023
PA450649norepinephrineChemicalPathwayassociated
PA451946yohimbineChemicalPathwayassociated
PA452618opioidsChemicalVariantAnnotationnot associatedPD21398039

References

Pubmed IDYearTitleCitations
390288222024Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury.0
390288222024Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury.0
370292952023Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders.4
373101792023The alpha-2A-adrenergic receptor gene polymorphism modulates gray matter structural networks, visual memory, and inhibitory cognitive control in children with attention deficit/hyperactivity disorder.0
378280252023ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon.4
370292952023Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders.4
373101792023The alpha-2A-adrenergic receptor gene polymorphism modulates gray matter structural networks, visual memory, and inhibitory cognitive control in children with attention deficit/hyperactivity disorder.0
378280252023ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon.4
349655032022The α(2)-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism.2
354291762022A pilot study of ADRA2A genotype association with doses of dexmedetomidine for sedation in pediatric patients.1
349655032022The α(2)-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism.2
354291762022A pilot study of ADRA2A genotype association with doses of dexmedetomidine for sedation in pediatric patients.1
294824742021Potential Role of ADRA2A Genetic Variants in the Etiology of ADHD Comorbid With Tic Disorders.3
341821282021Heteromerization between α(2A) adrenoceptors and different polymorphic variants of the dopamine D(4) receptor determines pharmacological and functional differences. Implications for impulsive-control disorders.5
342376562021α(2A)- and α(2C)-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects.5

Citation

Dessen P

ADRA2A (adrenoceptor alpha 2A)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55181/case-report-explorer/js/favicon/apple-touch-icon.png