CCT2 (chaperonin containing TCP1 subunit 2)

2015-05-01  

Identity

HGNC
LOCATION
12q15
LOCUSID
ALIAS
99D8.1,CCT-beta,CCTB,HEL-S-100n,PRO1633,TCP-1-beta
FUSION GENES

Other Information

Locus ID:

NCBI: 10576
MIM: 605139
HGNC: 1615
Ensembl: ENSG00000166226

Variants:

dbSNP: 10576
ClinVar: 10576
TCGA: ENSG00000166226
COSMIC: CCT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166226ENST00000299300P78371
ENSG00000166226ENST00000299300V9HW96
ENSG00000166226ENST00000543146P78371
ENSG00000166226ENST00000544368F5GWF6
ENSG00000166226ENST00000550010F8VQ14

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Folding of actin by CCT/TriCREACTOMER-HSA-390450
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
BBSome-mediated cargo-targeting to ciliumREACTOMER-HSA-5620922
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193325372009p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling.32
257047582015Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes.31
205738282010Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT.25
243754122014Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate β-tubulin folding.13
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
276457722016CCT2 Mutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability.9
237824732013Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma.8
231906062012Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivation.6
294836662018Uncovering the genetic lesions underlying the most severe form of Hirschsprung disease by whole-genome sequencing.4
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.3

Citation

Dessen P

CCT2 (chaperonin containing TCP1 subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55185/cct2