HSBP1 (heat shock factor binding protein 1)

2015-05-01  

Identity

HGNC
HSBP1
LOCATION
16q23.3
LOCUSID
3281
ALIAS
NPC-A-13
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3281
MIM: 604553
HGNC: 5203
Ensembl: ENSG00000230989

Variants:

dbSNP: 3281
ClinVar: 3281
TCGA: ENSG00000230989
COSMIC: HSBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000230989ENST00000433866O75506
ENSG00000230989ENST00000567382H3BR28
ENSG00000230989ENST00000570259O75506

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1 activationREACTOMER-HSA-3371511
HSF1-dependent transactivationREACTOMER-HSA-3371571
Attenuation phaseREACTOMER-HSA-3371568

References

Pubmed IDYearTitleCitations
323989612020Lin28A Regulates Stem-like Properties of Ovarian Cancer Cells by Enriching RAN and HSBP1 mRNA and Up-regulating its Protein Expression.7
323989612020Lin28A Regulates Stem-like Properties of Ovarian Cancer Cells by Enriching RAN and HSBP1 mRNA and Up-regulating its Protein Expression.7
310151262019The single nucleotide variant rs2868371 associates with the risk of mortality in non-small cell lung cancer patients: A multicenter prospective validation.4
310151262019The single nucleotide variant rs2868371 associates with the risk of mortality in non-small cell lung cancer patients: A multicenter prospective validation.4
293232802018Nucleotide exchange factors Fes1 and HspBP1 mimic substrate to release misfolded proteins from Hsp70.25
298440162018The trimeric coiled-coil HSBP1 protein promotes WASH complex assembly at centrosomes.11
293232802018Nucleotide exchange factors Fes1 and HspBP1 mimic substrate to release misfolded proteins from Hsp70.25
298440162018The trimeric coiled-coil HSBP1 protein promotes WASH complex assembly at centrosomes.11
283321482017pH-dependent structural modulation is conserved in the human small heat shock protein HSBP1.19
288282272017A novel p.T139M mutation in HSPB1 highlighting the phenotypic spectrum in a family.7
283321482017pH-dependent structural modulation is conserved in the human small heat shock protein HSBP1.19
288282272017A novel p.T139M mutation in HSPB1 highlighting the phenotypic spectrum in a family.7
248168432014Overexpression of HSBP1 is associated with resistance to radiotherapy in oral squamous epithelial carcinoma.5
248168432014Overexpression of HSBP1 is associated with resistance to radiotherapy in oral squamous epithelial carcinoma.5
212478892011The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex.8

Citation

Dessen P

HSBP1 (heat shock factor binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55192/css/lib/js/web-card-_common.js