GLIS3 (GLIS family zinc finger 3)

2015-09-01  

Identity

HGNC
LOCATION
9p24.2
LOCUSID
ALIAS
NDH,ZNF515
FUSION GENES

Other Information

Locus ID:

NCBI: 169792
MIM: 610192
HGNC: 28510
Ensembl: ENSG00000107249

Variants:

dbSNP: 169792
ClinVar: 169792
TCGA: ENSG00000107249
COSMIC: GLIS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107249ENST00000324333Q8NEA6
ENSG00000107249ENST00000324333A0A0S2Z689
ENSG00000107249ENST00000381971Q8NEA6
ENSG00000107249ENST00000462164Q1PHJ2
ENSG00000107249ENST00000477901Q1PHJ8
ENSG00000107249ENST00000478315Q1PHJ2
ENSG00000107249ENST00000478844Q1PHJ2
ENSG00000107249ENST00000481827Q1PHJ8
ENSG00000107249ENST00000491889F8WEV9
ENSG00000107249ENST00000645097A0A2R8YEK9

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200818582010New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.925
194304802009Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.655
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
167150982006Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.113
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
237377562013GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.55
188407812009Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.48
204194492010Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.43
215158492011Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children.39
219497442011Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes.28

Citation

Dessen P

GLIS3 (GLIS family zinc finger 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55386/glis3