OTUD4 (OTU deubiquitinase 4)

2015-09-01  

Identity

HGNC
LOCATION
4q31.21
LOCUSID
ALIAS
DUBA6,HIN1,HSHIN1
FUSION GENES

Other Information

Locus ID:

NCBI: 54726
MIM: 611744
HGNC: 24949
Ensembl: ENSG00000164164

Variants:

dbSNP: 54726
ClinVar: 54726
TCGA: ENSG00000164164
COSMIC: OTUD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164164ENST00000447906Q01804
ENSG00000164164ENST00000454497Q01804
ENSG00000164164ENST00000504501D6RA27
ENSG00000164164ENST00000509620Q01804
ENSG00000164164ENST00000514973D6RI06

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380400502024Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1.1
384292682024OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.1
385187212024NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma.0
380400502024Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1.1
384292682024OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.1
385187212024NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma.0
371498352023Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes.5
376424062023OTUD4 regulates metastasis and chemoresistance in melanoma by stabilizing Snail1.1
371498352023Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes.5
376424062023OTUD4 regulates metastasis and chemoresistance in melanoma by stabilizing Snail1.1
329732722020OTUD4 enhances TGFβ signalling through regulation of the TGFβ receptor complex.4
329732722020OTUD4 enhances TGFβ signalling through regulation of the TGFβ receptor complex.4
311386772019New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.12
311386772019New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.12
293950662018OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling.45

Citation

Dessen P

OTUD4 (OTU deubiquitinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55390/gene-explorer/haematological-explorer/js/web-card-gene.js