GPR37 (G protein-coupled receptor 37)

2015-09-01  

Identity

HGNC
GPR37
LOCATION
7q31.33
LOCUSID
2861
ALIAS
EDNRBL,PAELR,hET(B)R-LP

Other Information

Locus ID:

NCBI: 2861
MIM: 602583
HGNC: 4494
Ensembl: ENSG00000170775

Variants:

dbSNP: 2861
ClinVar: 2861
TCGA: ENSG00000170775
COSMIC: GPR37

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170775ENST00000303921O15354

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Parkinson's diseaseKEGGhsa05012
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
126704212003Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.94
236905942013GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.56
165396532006Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.46
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
197994512009GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions.19
186913892008Pael-R transgenic mice crossed with parkin deficient mice displayed progressive and selective catecholaminergic neuronal loss.18
145322702003A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.17
192184982009Induction of macroautophagy by overexpression of the Parkinson's disease-associated GPR37 receptor.17
232514432012Mutation in Parkinson disease-associated, G-protein-coupled receptor 37 (GPR37/PaelR) is related to autism spectrum disorder.17
270360492016REG4 promotes peritoneal metastasis of gastric cancer through GPR37.9

Citation

Dessen P

GPR37 (G protein-coupled receptor 37)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55392/gpr37-(g-protein-coupled-receptor-37)