SGPP1 (sphingosine-1-phosphate phosphatase 1)

2015-12-01  

Identity

HGNC
LOCATION
14q23.2
LOCUSID
ALIAS
SPP-1,SPPase1
FUSION GENES

Other Information

Locus ID:

NCBI: 81537
MIM: 612826
HGNC: 17720
Ensembl: ENSG00000126821

Variants:

dbSNP: 81537
ClinVar: 81537
TCGA: ENSG00000126821
COSMIC: SGPP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126821ENST00000247225Q9BX95

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
207986852011Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy.53
128150582003Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.49
221060152012Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition.45
178952502007Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2.44
241453502013miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1.37
251669142014Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2.36
220529052011Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage.32
167828912006Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.20
219409442011Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier.19
151809922004Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis.18

Citation

Dessen P

SGPP1 (sphingosine-1-phosphate phosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-12-01

Online version: http://atlasgeneticsoncology.org/gene/55542/sgpp1