RUFY3 (RUN and FYVE domain containing 3)

2015-12-01  

Identity

HGNC
RUFY3
LOCATION
4q13.3
LOCUSID
22902
ALIAS
RIPX,SINGAR1,ZFYVE30
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22902
MIM: 611194
HGNC: 30285
Ensembl: ENSG00000018189

Variants:

dbSNP: 22902
ClinVar: 22902
TCGA: ENSG00000018189
COSMIC: RUFY3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000018189ENST00000226328Q7L099
ENSG00000018189ENST00000226328A0A024RDD7
ENSG00000018189ENST00000381006Q7L099
ENSG00000018189ENST00000417478Q7L099
ENSG00000018189ENST00000502653Q7L099
ENSG00000018189ENST00000503876D6REM9
ENSG00000018189ENST00000504805H0Y8I0
ENSG00000018189ENST00000512103H0Y8G6
ENSG00000018189ENST00000513597D6RCQ1
ENSG00000018189ENST00000514898D6RH24

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
389150532024circSORBS1 inhibits lung cancer progression by sponging miR-6779-5p and directly binding RUFY3 mRNA.0
389150532024circSORBS1 inhibits lung cancer progression by sponging miR-6779-5p and directly binding RUFY3 mRNA.0
377976942023HPIP and RUFY3 are noncanonical guanine nucleotide exchange factors of Rab5 to regulate endocytosis-coupled focal adhesion turnover.0
377976942023HPIP and RUFY3 are noncanonical guanine nucleotide exchange factors of Rab5 to regulate endocytosis-coupled focal adhesion turnover.0
350185432022Low RUFY3 expression level is associated with lymph node metastasis in older women with invasive breast cancer.3
350185432022Low RUFY3 expression level is associated with lymph node metastasis in older women with invasive breast cancer.3
345100312021RUFY3 promotes the progression of hepatocellular carcinoma through activating NF-κB-mediated epithelial-mesenchymal transition.4
345100312021RUFY3 promotes the progression of hepatocellular carcinoma through activating NF-κB-mediated epithelial-mesenchymal transition.4
327442432020Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.3
327442432020Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.3
315478402019HOXD9 promotes the growth, invasion and metastasis of gastric cancer cells by transcriptional activation of RUFY3.33
315478402019HOXD9 promotes the growth, invasion and metastasis of gastric cancer cells by transcriptional activation of RUFY3.33
286233232017RUFY3 interaction with FOXK1 promotes invasion and metastasis in colorectal cancer.19
286233232017RUFY3 interaction with FOXK1 promotes invasion and metastasis in colorectal cancer.19
257663212015PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion.32

Citation

Dessen P

RUFY3 (RUN and FYVE domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-12-01

Online version: http://atlasgeneticsoncology.org/gene/55544/gene-explorer/css/template-nav.css