MAF1 (MAF1 homolog, negative regulator of RNA polymerase III)

2016-01-01  

Identity

HGNC
MAF1
LOCATION
8q24.3
LOCUSID
84232
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84232
MIM: 610210
HGNC: 24966
Ensembl: ENSG00000179632

Variants:

dbSNP: 84232
ClinVar: 84232
TCGA: ENSG00000179632
COSMIC: MAF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179632ENST00000322428Q9H063
ENSG00000179632ENST00000527058E9PR76
ENSG00000179632ENST00000527572E9PJ05
ENSG00000179632ENST00000532522Q9H063
ENSG00000179632ENST00000534585E9PSH4
ENSG00000179632ENST00000534811H0YEV4

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
336408832021Maf1 suppression of ATF5-dependent mitochondrial unfolded protein response contributes to rapamycin-induced radio-sensitivity in lung cancer cell line A549.7
336408832021Maf1 suppression of ATF5-dependent mitochondrial unfolded protein response contributes to rapamycin-induced radio-sensitivity in lung cancer cell line A549.7
320669622020Structural basis for RNA polymerase III transcription repression by Maf1.21
320669622020Structural basis for RNA polymerase III transcription repression by Maf1.21
306286582019Involvement of MAF1 homolog, negative regulator of RNA polymerase III in colorectal cancer progression.8
316454322019The RNA polymerase III repressor MAF1 is regulated by ubiquitin-dependent proteasome degradation and modulates cancer drug resistance and apoptosis.7
306286582019Involvement of MAF1 homolog, negative regulator of RNA polymerase III in colorectal cancer progression.8
316454322019The RNA polymerase III repressor MAF1 is regulated by ubiquitin-dependent proteasome degradation and modulates cancer drug resistance and apoptosis.7
269106472016MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription.41
269412512016Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest.42
269106472016MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription.41
269412512016Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest.42
255689452015Regulating maf1 expression and its expanding biological functions.6
260308422015A fluorescent bimolecular complementation screen reveals MAF1, RNF7 and SETD3 as PCNA-associated proteins in human cells.14
260672342015MAF1 represses CDKN1A through a Pol III-dependent mechanism.13

Citation

Dessen P

MAF1 (MAF1 homolog, negative regulator of RNA polymerase III)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/55576/deep-insight-explorer/css/lib/dataTables.bootstrap.min.css