UGT1A3 (UDP glucuronosyltransferase family 1 member A3)

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UGT1A3 (UDP glucuronosyltransferase family 1 member A3)

2016-01-01 Affiliation

Identity

HGNC

LOCATION

2q37.1

LOCUSID

ALIAS

UDPGT,UDPGT

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54659
MIM: 606428
HGNC: 12535
Ensembl: ENSG00000243135

Variants:

dbSNP: 54659
ClinVar: 54659
TCGA: ENSG00000243135
COSMIC: UGT1A3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000243135	ENST00000482026	P35503
ENSG00000243135	ENST00000482026	Q5DT01

Expression (GTEx)

0

1

2

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pentose and glucuronate interconversions	KEGG	ko00040
Ascorbate and aldarate metabolism	KEGG	ko00053
Steroid hormone biosynthesis	KEGG	ko00140
Retinol metabolism	KEGG	ko00830
Porphyrin and chlorophyll metabolism	KEGG	ko00860
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - other enzymes	KEGG	ko00983
Pentose and glucuronate interconversions	KEGG	hsa00040
Ascorbate and aldarate metabolism	KEGG	hsa00053
Steroid hormone biosynthesis	KEGG	hsa00140
Retinol metabolism	KEGG	hsa00830
Porphyrin and chlorophyll metabolism	KEGG	hsa00860
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Glucuronate pathway (uronate pathway)	KEGG	M00014
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Glucuronate pathway (uronate pathway)	KEGG	hsa_M00014
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glucuronidation	REACTOME	R-HSA-156588

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10251	atazanavir	Chemical	ClinicalAnnotation	associated		PD	17058217
PA133950441	hmg coa reductase inhibitors	Chemical	Pathway	associated
PA164760843	deferasirox	Chemical	ClinicalAnnotation	associated	PK	PD	27043265, 27193993, 28346059, 30651574
PA165110775	SN-38	Chemical	Pathway	associated
PA165958521	febuxostat	Chemical	ClinicalAnnotation	associated		PD	27798726
PA166123367	gepirone hydrochloride	Chemical	VariantAnnotation	not associated	PK		25192553
PA420	UGT1A1	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA443450	Asthma	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK		25192553, 28940478
PA444065	Epilepsy	Disease	ClinicalAnnotation	associated	PK		28763744
PA444318	Gout	Disease	ClinicalAnnotation	associated		PD	27798726
PA444511	Hyperbilirubinemia	Disease	ClinicalAnnotation	associated		PD	17058217
PA445601	Osteosarcoma	Disease	ClinicalAnnotation	associated	PK		29791011
PA446432	beta-Thalassemia	Disease	ClinicalAnnotation	associated	PK	PD	27043265, 27193993, 28346059, 30651574
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated		PD
PA447230	HIV	Disease	ClinicalAnnotation	associated		PD	17058217
PA448320	allopurinol	Chemical	ClinicalAnnotation	associated		PD	27798726
PA448500	atorvastatin	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	associated	PK	PD	22555810
PA449688	fluvastatin	Chemical	Pathway	associated
PA449957	ibuprofen	Chemical	Pathway	associated			25502615
PA450272	lovastatin	Chemical	Pathway	associated
PA450428	methotrexate	Chemical	ClinicalAnnotation	associated	PK		29791011
PA450546	montelukast	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK		28940478
PA451257	risperidone	Chemical	ClinicalAnnotation	associated		PD
PA451260	ritonavir	Chemical	ClinicalAnnotation	associated		PD	17058217
PA451363	simvastatin	Chemical	Pathway	associated
PA451846	valproic acid	Chemical	ClinicalAnnotation	associated	PK		28763744
PA451899	vitamin d and analogues	Chemical	Literature, MultilinkAnnotation	associated			24641623

References

Pubmed ID	Year	Title	Citations
34480602	2022	Evaluation of pharmacogenomics and hepatic nuclear imaging-related covariates by population pharmacokinetic models of irinotecan and its metabolites.	1
34480602	2022	Evaluation of pharmacogenomics and hepatic nuclear imaging-related covariates by population pharmacokinetic models of irinotecan and its metabolites.	1
33658628	2021	Identification of low-frequency variants of UGT1A3 associated with bladder cancer risk by next-generation sequencing.	5
33658628	2021	Identification of low-frequency variants of UGT1A3 associated with bladder cancer risk by next-generation sequencing.	5
32498119	2020	UGT1A3 and Sex Are Major Determinants of Telmisartan Pharmacokinetics-A Comprehensive Pharmacogenomic Study.	7
32498119	2020	UGT1A3 and Sex Are Major Determinants of Telmisartan Pharmacokinetics-A Comprehensive Pharmacogenomic Study.	7
30889488	2019	Combination of hesperetin and platinum enhances anticancer effect on lung adenocarcinoma.	13
30889488	2019	Combination of hesperetin and platinum enhances anticancer effect on lung adenocarcinoma.	13
28443723	2018	Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes.	15
28443723	2018	Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes.	15
25743847	2015	Increased UGT1A3 and UGT1A7 expression is associated with pancreatic cancer.	8
25743847	2015	Increased UGT1A3 and UGT1A7 expression is associated with pancreatic cancer.	8
24641623	2014	Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.	25
24641623	2014	Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.	25
23611809	2013	Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4.	13

Citation

Dessen P

UGT1A3 (UDP glucuronosyltransferase family 1 member A3)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/55580/favicon/js/lib/popper.js

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