CGB3 (chorionic gonadotropin subunit beta 3)

2016-01-01  

Identity

HGNC
CGB3
LOCATION
19q13.33
LOCUSID
1082
ALIAS
CGB,CGB5,CGB7,CGB8,LHB,hCGB

Other Information

Locus ID:

NCBI: 1082
MIM: 118860
HGNC: 1886
Ensembl: ENSG00000104827

Variants:

dbSNP: 1082
ClinVar: 1082
TCGA: ENSG00000104827
COSMIC: CGB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104827ENST00000357383P0DN86
ENSG00000104827ENST00000357383A0A0F7RQP8

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Peptide hormone biosynthesisREACTOMER-HSA-209952
Glycoprotein hormonesREACTOMER-HSA-209822
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsREACTOMER-HSA-8866910

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
346453612021A prospective cohort study on association of first-trimester serum biomarkers and risk of isolated foetal congenital heart defects.1
346453612021A prospective cohort study on association of first-trimester serum biomarkers and risk of isolated foetal congenital heart defects.1
313129592019Clinical characteristics and outcomes of extrauterine epithelioid trophoblastic tumors.2
313129592019Clinical characteristics and outcomes of extrauterine epithelioid trophoblastic tumors.2
293573212018B Subunit of Human Chorionic Gonadotropin Promotes Tumor Invasion and Predicts Poor Prognosis of Early-Stage Colorectal Cancer.7
300072472018Maternal concentrations of human chorionic gonadotropin (hCG) and risk for cerebral palsy (CP) in the child. A case control study.2
301973302018Immunohistochemical study of the expression of human chorionic gonadotropin-β in salivary gland tumors.2
293573212018B Subunit of Human Chorionic Gonadotropin Promotes Tumor Invasion and Predicts Poor Prognosis of Early-Stage Colorectal Cancer.7
300072472018Maternal concentrations of human chorionic gonadotropin (hCG) and risk for cerebral palsy (CP) in the child. A case control study.2
301973302018Immunohistochemical study of the expression of human chorionic gonadotropin-β in salivary gland tumors.2
280443772017Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells.18
280443772017Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells.18
265037852016A Positive Feedback Loop between Glial Cells Missing 1 and Human Chorionic Gonadotropin (hCG) Regulates Placental hCGβ Expression and Cell Differentiation.8
267027702016Occult abnormal pregnancies after first post-embryo transfer serum beta-human chorionic gonadotropin levels of 1.0-5.0 mIU/mL.0
269688392016An update on the clinical diagnostic value of β-hCG and αFP for intracranial germ cell tumors.11

Citation

Dessen P

CGB3 (chorionic gonadotropin subunit beta 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/55594/favicon/js/_common.js