ERBIN (erbb2 interacting protein)

2015-03-01  

Identity

HGNC
LOCATION
5q12.3
LOCUSID
ALIAS
ERBB2IP,HEL-S-78,LAP2
FUSION GENES

Other Information

Locus ID:

NCBI: 55914
MIM: 606944
HGNC: 15842
Ensembl: ENSG00000112851

Variants:

dbSNP: 55914
ClinVar: 55914
TCGA: ENSG00000112851
COSMIC: ERBIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112851ENST00000284037Q96RT1
ENSG00000112851ENST00000380935Q96RT1
ENSG00000112851ENST00000380938Q96RT1
ENSG00000112851ENST00000380943Q96RT1
ENSG00000112851ENST00000416865B4DIP2
ENSG00000112851ENST00000506030Q96RT1
ENSG00000112851ENST00000508515Q96RT1
ENSG00000112851ENST00000511297Q96RT1
ENSG00000112851ENST00000511671H0YA04
ENSG00000112851ENST00000512354H0Y9E8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB2REACTOMER-HSA-1227986
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
162037282005A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling.67
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
118214342002The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF.49
235249702013Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation.44
163013192006Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex.41
124440952003Novel mode of ligand recognition by the Erbin PDZ domain.38
167379692006Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.37
123796592003Erbin suppresses the MAP kinase pathway.35
175917012007Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain.21
120473492002ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells.13

Citation

Dessen P

ERBIN (erbb2 interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55621/erbin