ERBIN (erbb2 interacting protein)

2015-03-01  

Identity

HGNC
ERBIN
LOCATION
5q12.3
LOCUSID
55914
ALIAS
ERBB2IP,HEL-S-78,LAP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55914
MIM: 606944
HGNC: 15842
Ensembl: ENSG00000112851

Variants:

dbSNP: 55914
ClinVar: 55914
TCGA: ENSG00000112851
COSMIC: ERBIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112851ENST00000284037Q96RT1
ENSG00000112851ENST00000380935Q96RT1
ENSG00000112851ENST00000380938Q96RT1
ENSG00000112851ENST00000380943Q96RT1
ENSG00000112851ENST00000416865B4DIP2
ENSG00000112851ENST00000506030Q96RT1
ENSG00000112851ENST00000508515Q96RT1
ENSG00000112851ENST00000511297Q96RT1
ENSG00000112851ENST00000511671H0YA04
ENSG00000112851ENST00000512354H0Y9E8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB2REACTOMER-HSA-1227986
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382327362024Targeting Erbin-mitochondria axis in platelets/megakaryocytes promotes B cell-mediated antitumor immunity.1
382327362024Targeting Erbin-mitochondria axis in platelets/megakaryocytes promotes B cell-mediated antitumor immunity.1
371927462023Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non-small cell lung carcinoma.5
371927462023Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non-small cell lung carcinoma.5
325582432021The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease.11
337074282021Targeting Erbin in B cells for therapy of lung metastasis of colorectal cancer.8
325582432021The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease.11
337074282021Targeting Erbin in B cells for therapy of lung metastasis of colorectal cancer.8
303675122019Erbin plays a critical role in human umbilical vein endothelial cell migration and tubular structure formation via the Smad1/5 pathway.3
305513642019LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis.35
306553202019Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner.11
303675122019Erbin plays a critical role in human umbilical vein endothelial cell migration and tubular structure formation via the Smad1/5 pathway.3
305513642019LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis.35
306553202019Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner.11
299805712018Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer.17

Citation

Dessen P

ERBIN (erbb2 interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55621/gene-fusions/teaching-explorer/css/template-card.css