AGGF1 (angiogenic factor with G-patch and FHA domains 1)

2016-04-01  

Identity

HGNC
LOCATION
5q13.3
LOCUSID
ALIAS
GPATC7,GPATCH7,HSU84971,HUS84971,VG5Q
FUSION GENES

Other Information

Locus ID:

NCBI: 55109
MIM: 608464
HGNC: 24684
Ensembl: ENSG00000164252

Variants:

dbSNP: 55109
ClinVar: 55109
TCGA: ENSG00000164252
COSMIC: AGGF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164252ENST00000312916Q8N302
ENSG00000164252ENST00000502408H0Y8F8
ENSG00000164252ENST00000506806Q8N302

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

References

Pubmed IDYearTitleCitations
149611212004Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome.66
244627382014Role of microRNA-27a in down-regulation of angiogenic factor AGGF1 under hypoxia associated with high-grade bladder urothelial carcinoma.23
195562472009Novel roles of GATA1 in regulation of angiogenic factor AGGF1 and endothelial cell function.22
169113692006Klippel-Trenaunay syndrome: a multisystem disorder possibly resulting from a pathogenic gene for vascular and tissue overgrowth.18
185641292008Identification of association of common AGGF1 variants with susceptibility for Klippel-Trenaunay syndrome using the structure association program.16
185641292008Identification of association of common AGGF1 variants with susceptibility for Klippel-Trenaunay syndrome using the structure association program.16
248939932014AGGF1 protects from myocardial ischemia/reperfusion injury by regulating myocardial apoptosis and angiogenesis.16
257965012015Overexpression of AGGF1 is correlated with angiogenesis and poor prognosis of hepatocellular carcinoma.16
236287012013AGGF1 is a novel anti-inflammatory factor associated with TNF-α-induced endothelial activation.14
282892722017High Expression of Angiogenic Factor with G-Patch and FHA Domain1 (AGGF1) Predicts Poor Prognosis in Gastric Cancer.11

Citation

Dessen P

AGGF1 (angiogenic factor with G-patch and FHA domains 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55701/aggf1-(angiogenic-factor-with-g-patch-and-fha-domains-1)