KREMEN1 (kringle containing transmembrane protein 1)

2016-04-01  

Identity

HGNC
KREMEN1
LOCATION
22q12.1
LOCUSID
83999
ALIAS
ECTD13,KREMEN,KRM1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83999
MIM: 609898
HGNC: 17550
Ensembl: ENSG00000183762

Variants:

dbSNP: 83999
ClinVar: 83999
TCGA: ENSG00000183762
COSMIC: KREMEN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183762ENST00000327813Q96MU8
ENSG00000183762ENST00000400335Q96MU8
ENSG00000183762ENST00000407188Q96MU8
ENSG00000183762ENST00000453585H7BZ87

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by WNT in cancerREACTOMER-HSA-4791275
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signalingREACTOMER-HSA-5339717
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Negative regulation of TCF-dependent signaling by WNT ligand antagonistsREACTOMER-HSA-3772470

References

Pubmed IDYearTitleCitations
209356292010Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.396
120506702002Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.292
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
185027622008Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.35
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
230418402013Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis.18
201531412010Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population.10
201531412010Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population.10
275242012016Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf.7

Citation

Dessen P

KREMEN1 (kringle containing transmembrane protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55727/kremen1