GLE1 (GLE1 RNA export mediator)

2016-05-01  

Identity

HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
CAAHC,CAAHD,GLE1L,LCCS,LCCS1,hGLE1
FUSION GENES

Other Information

Locus ID:

NCBI: 2733
MIM: 603371
HGNC: 4315
Ensembl: ENSG00000119392

Variants:

dbSNP: 2733
ClinVar: 2733
TCGA: ENSG00000119392
COSMIC: GLE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119392ENST00000309971Q53GS7
ENSG00000119392ENST00000372770Q53GS7

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
182044492008Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
253439932015Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis.48
220644662011Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export.44
160003792005Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA.40
242430162013Gle1 functions during mRNA export in an oligomeric complex that is altered in human disease.34
223579252012A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization.28
256944492015Cytoplasmic hGle1A regulates stress granules by modulation of translation.17
242754322014Insights into mRNA export-linked molecular mechanisms of human disease through a Gle1 structure-function analysis.13
266559972016Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.11

Citation

Dessen P

GLE1 (GLE1 RNA export mediator)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55781/gle1