KMO (kynurenine 3-monooxygenase)

2016-05-01  

Identity

HGNC
KMO
LOCATION
1q43
LOCUSID
8564
ALIAS
dJ317G22.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8564
MIM: 603538
HGNC: 6381
Ensembl: ENSG00000117009

Variants:

dbSNP: 8564
ClinVar: 8564
TCGA: ENSG00000117009
COSMIC: KMO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117009ENST00000366555H0Y320
ENSG00000117009ENST00000366557O15229
ENSG00000117009ENST00000366558O15229
ENSG00000117009ENST00000366559O15229

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tryptophan metabolismKEGGko00380
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Tryptophan catabolismREACTOMER-HSA-71240
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384971132024Kynurenine 3-monooxygenase limits de novo NAD(+) synthesis through dietary tryptophan in renal proximal tubule epithelial cell models.1
384971132024Kynurenine 3-monooxygenase limits de novo NAD(+) synthesis through dietary tryptophan in renal proximal tubule epithelial cell models.1
350115052022The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors.16
350115052022The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors.16
344407982021Kynurenine Monooxygenase Expression and Activity in Human Astrocytomas.5
344407982021Kynurenine Monooxygenase Expression and Activity in Human Astrocytomas.5
322682682020Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression.20
323900082020Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion.14
331708362020A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics.9
322682682020Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression.20
323900082020Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion.14
331708362020A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics.9
283196972017Genetic variants of the kynurenine-3-monooxygenase and postpartum depressive symptoms after cesarean section in Chinese women.12
283196972017Genetic variants of the kynurenine-3-monooxygenase and postpartum depressive symptoms after cesarean section in Chinese women.12
265898322016Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors.32

Citation

Dessen P

KMO (kynurenine 3-monooxygenase)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55782/case-report-explorer/css/js/_common.js