OAS2 (2-5-oligoadenylate synthetase 2)

2016-06-01  

Identity

HGNC
LOCATION
12q24.13
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 4939
MIM: 603350
HGNC: 8087
Ensembl: ENSG00000111335

Variants:

dbSNP: 4939
ClinVar: 4939
TCGA: ENSG00000111335
COSMIC: OAS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111335ENST00000342315P29728
ENSG00000111335ENST00000392583P29728
ENSG00000111335ENST00000449768P29728
ENSG00000111335ENST00000551603F8VPI5
ENSG00000111335ENST00000552756F8W1C5
ENSG00000111335ENST00000620097A0A087X0V5

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198539192009Nucleotide oligomerization domain-2 interacts with 2'-5'-oligoadenylate synthetase type 2 and enhances RNase-L function in THP-1 cells.27
210501262010Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.24
210501262010Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.24
160146972006Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?23
278991332016Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.20
233376122013Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection.14
124478672002Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study.12
205883082010Dengue hemorrhagic fever is associated with polymorphisms in JAK1.9
195590552009A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients.6
275729592016Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites.6

Citation

Dessen P

OAS2 (2-5-oligoadenylate synthetase 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-06-01

Online version: http://atlasgeneticsoncology.org/gene/55798/oas2