MN1 (meningioma 1)

1997-10-01   Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
22q12.1
LOCUSID
ALIAS
CEBALID,MGCR,MGCR1,MGCR1-PEN,dJ353E16.2
FUSION GENES

DNA/RNA

Description

2 exons at least, the first being very CG rich and with CAG repeats; spans about 70 kb

Transcription

alternate splicing: 4.5 and 8 kb mRNA; coding sequence: 4.0 kb

Proteins

Description

1319 and 1342 amino acids; glutamine and prolin rich (may function as transactivation domains)

Expression

ubiquitously expressed; high expression in muscle, low otherwise

Function

transcriptionnal regulator

Implicated in

Entity name
t(12;22)(p13;q11) /myeloid malignancies --> MN1-ETV6
Disease
M4 AML and other myeloid malignancies (MDS ...)
Prognosis
yet uncertain; median survival 2yrs
Cytogenetics
additional anomalies: +8
Hybrid gene
5 MN1 - 3 ETV6
Fusion protein
N-term MN1 and most of it, comprising the glutamine/proline rich domain, fused to the DNA binding of ETV6 in C-term; nuclear protein
Oncogenesis
may act as an altered transcription factor
Entity name
meningioma (some of them)

Bibliography

Pubmed IDLast YearTitleAuthors
77317051995Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.Buijs A et al
77317061995Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma.Lekanne Deprez RH et al

Other Information

Locus ID:

NCBI: 4330
MIM: 156100
HGNC: 7180
Ensembl: ENSG00000169184

Variants:

dbSNP: 4330
ClinVar: 4330
TCGA: ENSG00000169184
COSMIC: MN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169184ENST00000302326Q10571
ENSG00000169184ENST00000302326A0A024R1C3
ENSG00000169184ENST00000424656H7C105

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
194514322009Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study.50
174948592007MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.41
175257182007MN1 overexpression is an important step in the development of inv(16) AML.30
218281252011Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia.26
158906722005The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation.18
200721572010Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia.16
161059792005Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9.14
195613242009Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.13
269276742016MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.13

Citation

Jean-Loup Huret

MN1 (meningioma 1)

Atlas Genet Cytogenet Oncol Haematol. 1997-10-01

Online version: http://atlasgeneticsoncology.org/gene/56/mn1-(meningioma-1)