ACSL6 (acyl-CoA synthetase long chain family member 6)

2003-02-01  

Identity

HGNC
LOCATION
5q31.1
LOCUSID
ALIAS
ACS2,FACL6,LACS
FUSION GENES

Other Information

Locus ID:

NCBI: 23305
MIM: 604443
HGNC: 16496
Ensembl: ENSG00000164398

Variants:

dbSNP: 23305
ClinVar: 23305
TCGA: ENSG00000164398
COSMIC: ACSL6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164398ENST00000296869A0A499FJL5
ENSG00000164398ENST00000357096Q9UKU0
ENSG00000164398ENST00000379240Q9UKU0
ENSG00000164398ENST00000379244Q9UKU0
ENSG00000164398ENST00000379246Q9UKU0
ENSG00000164398ENST00000379255Q9UKU0
ENSG00000164398ENST00000414078C9JPA5
ENSG00000164398ENST00000416557C9J4I1
ENSG00000164398ENST00000419502C9JK59
ENSG00000164398ENST00000430403C9J3Z0
ENSG00000164398ENST00000431707E7ERD7
ENSG00000164398ENST00000434099C9J8C7
ENSG00000164398ENST00000441995C9JT10
ENSG00000164398ENST00000543479Q9UKU0
ENSG00000164398ENST00000650697A0A494C0B6
ENSG00000164398ENST00000650912A0A494C1I9
ENSG00000164398ENST00000651086A0A494C0V0
ENSG00000164398ENST00000651250A0A494C0J9
ENSG00000164398ENST00000651269A0A494C0D5
ENSG00000164398ENST00000651356Q9UKU0
ENSG00000164398ENST00000651427A0A494BZW8
ENSG00000164398ENST00000651454A0A494C046
ENSG00000164398ENST00000651883Q9UKU0
ENSG00000164398ENST00000652424A0A494C005
ENSG00000164398ENST00000652493A0A494C0A5

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Fatty acid biosynthesisKEGGko00061
Fatty acid degradationKEGGko00071
PPAR signaling pathwayKEGGko03320
Adipocytokine signaling pathwayKEGGko04920
Fatty acid biosynthesisKEGGhsa00061
Fatty acid degradationKEGGhsa00071
PPAR signaling pathwayKEGGhsa03320
Adipocytokine signaling pathwayKEGGhsa04920
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
beta-Oxidation, acyl-CoA synthesisKEGGhsa_M00086
beta-Oxidation, acyl-CoA synthesisKEGGM00086
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Synthesis of very long-chain fatty acyl-CoAsREACTOMER-HSA-75876
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
170305542006Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia.26
170305542006Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia.26
204299312010Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains.21
190645712008Polymorphisms in mitochondrial genes and prostate cancer risk.20
168347752006Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains.16
188043462008Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.10
276474152017Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle.10
168279192007DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia.7
168279192007DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia.7

Citation

Dessen P

ACSL6 (acyl-CoA synthetase long chain family member 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/560/acsl6