ACSL6 (acyl-CoA synthetase long chain family member 6)

2003-02-01  

Identity

HGNC
ACSL6
LOCATION
5q31.1
LOCUSID
23305
ALIAS
ACS2,FACL6,LACS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23305
MIM: 604443
HGNC: 16496
Ensembl: ENSG00000164398

Variants:

dbSNP: 23305
ClinVar: 23305
TCGA: ENSG00000164398
COSMIC: ACSL6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164398ENST00000296869A0A499FJL5
ENSG00000164398ENST00000357096Q9UKU0
ENSG00000164398ENST00000379240Q9UKU0
ENSG00000164398ENST00000379244Q9UKU0
ENSG00000164398ENST00000379246Q9UKU0
ENSG00000164398ENST00000379255Q9UKU0
ENSG00000164398ENST00000414078C9JPA5
ENSG00000164398ENST00000416557C9J4I1
ENSG00000164398ENST00000419502C9JK59
ENSG00000164398ENST00000430403C9J3Z0
ENSG00000164398ENST00000431707E7ERD7
ENSG00000164398ENST00000434099C9J8C7
ENSG00000164398ENST00000441995C9JT10
ENSG00000164398ENST00000543479Q9UKU0
ENSG00000164398ENST00000650697A0A494C0B6
ENSG00000164398ENST00000650912A0A494C1I9
ENSG00000164398ENST00000651086A0A494C0V0
ENSG00000164398ENST00000651250A0A494C0J9
ENSG00000164398ENST00000651269A0A494C0D5
ENSG00000164398ENST00000651356Q9UKU0
ENSG00000164398ENST00000651427A0A494BZW8
ENSG00000164398ENST00000651454A0A494C046
ENSG00000164398ENST00000651883Q9UKU0
ENSG00000164398ENST00000652424A0A494C005
ENSG00000164398ENST00000652493A0A494C0A5

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fatty acid biosynthesisKEGGko00061
Fatty acid degradationKEGGko00071
PPAR signaling pathwayKEGGko03320
Adipocytokine signaling pathwayKEGGko04920
Fatty acid biosynthesisKEGGhsa00061
Fatty acid degradationKEGGhsa00071
PPAR signaling pathwayKEGGhsa03320
Adipocytokine signaling pathwayKEGGhsa04920
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
beta-Oxidation, acyl-CoA synthesisKEGGhsa_M00086
beta-Oxidation, acyl-CoA synthesisKEGGM00086
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Synthesis of very long-chain fatty acyl-CoAsREACTOMER-HSA-75876
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
346025682021Substrate Specificity of Human Long-Chain Acyl-CoA Synthetase ACSL6 Variants.1
346025682021Substrate Specificity of Human Long-Chain Acyl-CoA Synthetase ACSL6 Variants.1
316485592019Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice.11
316485592019Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice.11
276474152017Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle.27
276474152017Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle.27
222059692011ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.8
222059692011ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.8
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
204299312010Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains.26
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
204299312010Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains.26
185552212009Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure.3
185552212009Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure.3
185552212009Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure.3

Citation

Dessen P

ACSL6 (acyl-CoA synthetase long chain family member 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/560/case-report-explorer/css/meetings/js/lib/jquery-3.5.1.min.js