DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor)

2016-10-01  

Identity

HGNC
DIMT1
LOCATION
5q12.1
LOCUSID
27292
ALIAS
DIM1,DIMT1L,HSA9761,HUSSY5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27292
MIM: 612499
HGNC: 30217
Ensembl: ENSG00000086189

Variants:

dbSNP: 27292
ClinVar: 27292
TCGA: ENSG00000086189
COSMIC: DIMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086189ENST00000199320Q9UNQ2
ENSG00000086189ENST00000506390A0A0C4DGB1
ENSG00000086189ENST00000514911D6RCL3
ENSG00000086189ENST00000651114A0A494C0G7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
rRNA modification in the nucleus and cytosolREACTOMER-HSA-6790901
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370242832023Noncatalytic regulation of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia.1
370242832023Noncatalytic regulation of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia.1
351489932022Ribosomal biogenesis regulator DIMT1 controls β-cell protein synthesis, mitochondrial function, and insulin secretion.6
351489932022Ribosomal biogenesis regulator DIMT1 controls β-cell protein synthesis, mitochondrial function, and insulin secretion.6
344739912021Human DIMT1 generates N(2)(6,6)A-dimethylation-containing small RNAs.3
344739912021Human DIMT1 generates N(2)(6,6)A-dimethylation-containing small RNAs.3
326166532020Structural and catalytic roles of the human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation.13
326166532020Structural and catalytic roles of the human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation.13
281644102017Hypoxia-inducible microRNA-210 regulates the DIMT1-IRF4 oncogenic axis in multiple myeloma.22
286016612017DIMT1 overexpression correlates with progression and prognosis in gastric carcinoma.5
281644102017Hypoxia-inducible microRNA-210 regulates the DIMT1-IRF4 oncogenic axis in multiple myeloma.22
286016612017DIMT1 overexpression correlates with progression and prognosis in gastric carcinoma.5
258516042015The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.81
258516042015The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.81
251871772014Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection.53

Citation

Dessen P

DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56066/css/js/lib/css/template-card.css