NDFIP1 (Nedd4 family interacting protein 1)

2016-10-01  

Identity

HGNC
LOCATION
5q31.3
LOCUSID
ALIAS
N4WBP5
FUSION GENES

Other Information

Locus ID:

NCBI: 80762
MIM: 612050
HGNC: 17592
Ensembl: ENSG00000131507

Variants:

dbSNP: 80762
ClinVar: 80762
TCGA: ENSG00000131507
COSMIC: NDFIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131507ENST00000253814Q9BT67

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193430522009Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.64
188199142008Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins.44
230874042012Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation.42
197068932009Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.32
205345352010Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.24
244752382014Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels.8
256310462015Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.8
263630032015Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).7
293339442017MiR-155 Promotes Uveal Melanoma Cell Proliferation and Invasion by Regulating NDFIP1 Expression.6
211872862011Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes.3

Citation

Dessen P

NDFIP1 (Nedd4 family interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56091/ndfip1