GAREM1 (GRB2 associated regulator of MAPK1 subtype 1)

2016-10-01  

Identity

HGNC
LOCATION
18q12.1
LOCUSID
ALIAS
C18orf11,FAM59A,GAREM,Gm944

Other Information

Locus ID:

NCBI: 64762
MIM: 617998
HGNC: 26136
Ensembl: ENSG00000141441

Variants:

dbSNP: 64762
ClinVar: 64762
TCGA: ENSG00000141441
COSMIC: GAREM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141441ENST00000269209Q9H706
ENSG00000141441ENST00000399218Q9H706
ENSG00000141441ENST00000583696J3QRF3

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
195092912009GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.16
240032232013A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling.6
261642322015Functional relationship between CABIT, SAM and 14-3-3 binding domains of GAREM1 that play a role in its subcellular localization.2
301773872018MicroRNA-128 contributes to the progression of gastric carcinoma through GAREM-mediated MAPK signaling activation.2
292737312018GAREM1 regulates the PR interval on electrocardiograms.0

Citation

Dessen P

GAREM1 (GRB2 associated regulator of MAPK1 subtype 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56129/garem1