IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker))

2016-10-01  

Identity

HGNC
LOCATION
14q32.33
LOCUSID
ALIAS
IgG3
FUSION GENES

Other Information

Locus ID:

NCBI: 3502
MIM: 147120
HGNC: 5527
Ensembl: ENSG00000211897
IMGT/GENE-DB:

Variants:

dbSNP: 3502
ClinVar: 3502
TCGA: ENSG00000211897
COSMIC: IGHG3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000211897ENST00000390551A0A4W9A917
ENSG00000211897ENST00000641136A0A286YES1

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Initial triggering of complementREACTOMER-HSA-166663
Creation of C4 and C2 activatorsREACTOMER-HSA-166786
Classical antibody-mediated complement activationREACTOMER-HSA-173623
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485

References

Pubmed IDYearTitleCitations
262323282015Insights into the effector functions of human IgG3 in the context of an antibody targeting transferrin receptor 1.6
301046332018IgG3 regulates tissue-like memory B cells in HIV-infected individuals.5
301162492018The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts.5
195426242009Immunoglobulin GM genes as functional risk and protective factors for the development of Alzheimer's disease.3
246193122014Haemoglobin levels in autoimmune haemolytic anaemias at diagnosis: relationship with immunoproteins on red blood cells.1
299453072018Demonstration of IgG Subclass (IgG1 and IgG3) in Immuno-Related Hemocytopenia.1
179335032008Association between Gm allotypes and asthma severity from childhood to young middle age.0

Citation

Dessen P

IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker))

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56144/ighg3