CPLX1 (complexin 1)

2016-10-01  

Identity

HGNC
CPLX1
LOCATION
4p16.3
LOCUSID
10815
ALIAS
CPX-I,CPX1,DEE63,EIEE63
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10815
MIM: 605032
HGNC: 2309
Ensembl: ENSG00000168993

Variants:

dbSNP: 10815
ClinVar: 10815
TCGA: ENSG00000168993
COSMIC: CPLX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168993ENST00000304062O14810
ENSG00000168993ENST00000504062D6RAG3
ENSG00000168993ENST00000505203D6RI11

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Norepinephrine Neurotransmitter Release CycleREACTOMER-HSA-181430
Serotonin Neurotransmitter Release CycleREACTOMER-HSA-181429
Glutamate Neurotransmitter Release CycleREACTOMER-HSA-210500
Dopamine Neurotransmitter Release CycleREACTOMER-HSA-212676
Acetylcholine Neurotransmitter Release CycleREACTOMER-HSA-264642
GABA synthesis, release, reuptake and degradationREACTOMER-HSA-888590

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
324011942020Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis.22
324011942020Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis.22
278662312017Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.21
281084692017Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.12
284221312017Variants in CPLX1 in two families with autosomal-recessive severe infantile myoclonic epilepsy and ID.18
291183712017Genetic association analysis of microRNA137 and its target complex 1 with schizophrenia in Han Chinese.2
278662312017Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.21
281084692017Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.12
284221312017Variants in CPLX1 in two families with autosomal-recessive severe infantile myoclonic epilepsy and ID.18
291183712017Genetic association analysis of microRNA137 and its target complex 1 with schizophrenia in Han Chinese.2
265771842016Increased complexin-1 and decreased miR-185 expression levels in Behçet's disease with and without neurological involvement.4
265771842016Increased complexin-1 and decreased miR-185 expression levels in Behçet's disease with and without neurological involvement.4
258319642015Re-visiting the trans insertion model for complexin clamping.24
262453032015Complexins: small but capable.34
266039342015Carboxypeptidase X-1 (CPX-1) is a secreted collagen-binding glycoprotein.11

Citation

Dessen P

CPLX1 (complexin 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56183/deep-insight-explorer/img/logo-atlas-4.svg