MIEF2 (mitochondrial elongation factor 2)

2016-10-01 Affiliation

Identity

HGNC

MIEF2

LOCATION

17p11.2

LOCUSID

125170

ALIAS

COXPD49,MID49,SMCR7

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 125170
MIM: 615498
HGNC: 17920
Ensembl: ENSG00000177427

Variants:

dbSNP: 125170
ClinVar: 125170
TCGA: ENSG00000177427
COSMIC: MIEF2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000177427	ENST00000323019	Q96C03
ENSG00000177427	ENST00000395703	A8MT25
ENSG00000177427	ENST00000395704	Q96C03
ENSG00000177427	ENST00000395706	Q96C03
ENSG00000177427	ENST00000578174	J3KTJ4
ENSG00000177427	ENST00000578621	J3QR30
ENSG00000177427	ENST00000579341	K7EKV6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10066	duloxetine	Chemical	ClinicalAnnotation	associated		PD	29407288
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated		PD	29407288

References

Pubmed ID	Year	Title	Citations
33414447	2021	MIEF2 reprograms lipid metabolism to drive progression of ovarian cancer through ROS/AKT/mTOR signaling pathway.	42
33414447	2021	MIEF2 reprograms lipid metabolism to drive progression of ovarian cancer through ROS/AKT/mTOR signaling pathway.	42
32068312	2020	An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.	9
32236517	2020	Mitochondrial fragmentation enables localized signaling required for cell repair.	30
33317572	2020	MIEF2 over-expression promotes tumor growth and metastasis through reprogramming of glucose metabolism in ovarian cancer.	14
32068312	2020	An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.	9
32236517	2020	Mitochondrial fragmentation enables localized signaling required for cell repair.	30
33317572	2020	MIEF2 over-expression promotes tumor growth and metastasis through reprogramming of glucose metabolism in ovarian cancer.	14
29431643	2018	Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.	82
29899447	2018	Structural basis of mitochondrial receptor binding and constriction by DRP1.	158
29431643	2018	Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.	82
29899447	2018	Structural basis of mitochondrial receptor binding and constriction by DRP1.	158
28137654	2017	Foxo3a inhibits mitochondrial fission and protects against doxorubicin-induced cardiotoxicity by suppressing MIEF2.	27
28137654	2017	Foxo3a inhibits mitochondrial fission and protects against doxorubicin-induced cardiotoxicity by suppressing MIEF2.	27
26564796	2016	Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein.	70

Citation

Dessen P

MIEF2 (mitochondrial elongation factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56427/cancer-prone-explorer/favicon/favicon-32x32.png