RHOT2 (ras homolog family member T2)

2016-10-01 Affiliation

Identity

HGNC

RHOT2

LOCATION

16p13.3

LOCUSID

89941

ALIAS

ARHT2,C16orf39,MIRO-2,MIRO2,RASL

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 89941
MIM: 613889
HGNC: 21169
Ensembl: ENSG00000140983

Variants:

dbSNP: 89941
ClinVar: 89941
TCGA: ENSG00000140983
COSMIC: RHOT2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000140983	ENST00000315082	Q8IXI1
ENSG00000140983	ENST00000561929	H3BST5
ENSG00000140983	ENST00000561983	H3BUX4
ENSG00000140983	ENST00000562333	H3BUX4
ENSG00000140983	ENST00000563134	I3L2C6
ENSG00000140983	ENST00000563637	H3BVI5
ENSG00000140983	ENST00000566214	H3BP40
ENSG00000140983	ENST00000569197	H3BU27
ENSG00000140983	ENST00000570280	H3BMP9

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
Mitophagy - animal	KEGG	ko04137
Mitophagy - animal	KEGG	hsa04137

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34992146	2022	MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling.	6
34992146	2022	MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling.	6
32948353	2021	The role of RHOT1 and RHOT2 genetic variation on Parkinson disease risk and onset.	0
32948353	2021	The role of RHOT1 and RHOT2 genetic variation on Parkinson disease risk and onset.	0
33132189	2020	Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase.	12
33132189	2020	Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase.	12
30787202	2019	Epigenetic signature: implications for mitochondrial quality control in human aging.	9
30787202	2019	Epigenetic signature: implications for mitochondrial quality control in human aging.	9
30111583	2018	Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.	49
30459446	2018	GBF1 and Arf1 interact with Miro and regulate mitochondrial positioning within cells.	16
30513825	2018	Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism.	10
30111583	2018	Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.	49
30459446	2018	GBF1 and Arf1 interact with Miro and regulate mitochondrial positioning within cells.	16
30513825	2018	Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism.	10
27605430	2016	Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.	29

Citation

Dessen P

RHOT2 (ras homolog family member T2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56494/css/lib/gene-fusions/favicon/favicon-16x16.png