MAGT1 (magnesium transporter 1)

2016-10-01  

Identity

HGNC
MAGT1
LOCATION
Xq21.1
LOCUSID
84061
ALIAS
CDG1CC,IAP,MRX95,OST3B,PRO0756,SLC58A1,XMEN,bA217H1.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84061
MIM: 300715
HGNC: 28880
Ensembl: ENSG00000102158

Variants:

dbSNP: 84061
ClinVar: 84061
TCGA: ENSG00000102158
COSMIC: MAGT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102158ENST00000358075A0A087WU53
ENSG00000102158ENST00000373336Q9H0U3
ENSG00000102158ENST00000610432A0A087WU53
ENSG00000102158ENST00000618282Q9H0U3

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Miscellaneous transport and binding eventsREACTOMER-HSA-5223345
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
197174682009Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development.65
184551292008Oligosaccharyltransferase-subunit mutations in nonsyndromic mental retardation.52
158043572005Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties.46
216279702011The Mg2+ transporter MagT1 partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7.22
219831752011Loss of MAGT1 abrogates the Mg2+ flux required for T cell signaling and leads to a novel human primary immunodeficiency.14
266176902015Up-regulation of AKAP13 and MAGT1 on cytoplasmic membrane in progressive hepatocellular carcinoma: a novel target for prognosis.5
303858062018TRPM7 and MagT1 in the osteogenic differentiation of human mesenchymal stem cells in vitro.5
313377042019Magnesium transporter 1 (MAGT1) deficiency causes selective defects in N-linked glycosylation and expression of immune-response genes.4
241301522014Variant ATRX syndrome with dysfunction of ATRX and MAGT1 genes.3
309524252019The simultaneous downregulation of TRPM7 and MagT1 in human mesenchymal stem cells in vitro: Effects on growth and osteogenic differentiation.1

Citation

Dessen P

MAGT1 (magnesium transporter 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56622/magt1