TLE4 (TLE family member 4, transcriptional corepressor)

2016-12-01  

Identity

HGNC
TLE4
LOCATION
9q21.31
LOCUSID
7091
ALIAS
BCE-1,BCE1,E(spI),E(spl),ESG,ESG4,GRG4,Grg-4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7091
MIM: 605132
HGNC: 11840
Ensembl: ENSG00000106829

Variants:

dbSNP: 7091
ClinVar: 7091
TCGA: ENSG00000106829
COSMIC: TLE4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106829ENST00000265284Q04727
ENSG00000106829ENST00000376537Q04727
ENSG00000106829ENST00000376544Q04727
ENSG00000106829ENST00000376552Q04727
ENSG00000106829ENST00000414465Q5JSZ2
ENSG00000106829ENST00000417836H0Y5S0
ENSG00000106829ENST00000425506Q5JSY8
ENSG00000106829ENST00000428713Q5JSY7
ENSG00000106829ENST00000435650Q5JSZ1
ENSG00000106829ENST00000461758A0A0A0MT79
ENSG00000106829ENST00000462803E7EQH3
ENSG00000106829ENST00000467142H7C4W5
ENSG00000106829ENST00000470872F8WAY5
ENSG00000106829ENST00000490347H7C4P7
ENSG00000106829ENST00000496114H7C4E4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

References

Pubmed IDYearTitleCitations
350990082022TLE4 regulates muscle stem cell quiescence and skeletal muscle differentiation.9
350990082022TLE4 regulates muscle stem cell quiescence and skeletal muscle differentiation.9
282623902017Polymorphisms of TGFB1, TLE4 and MUC22 are associated with childhood asthma in Chinese population.8
282623902017Polymorphisms of TGFB1, TLE4 and MUC22 are associated with childhood asthma in Chinese population.8
267012082016TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway.27
274860622016TLE4 regulation of wnt-mediated inflammation underlies its role as a tumor suppressor in myeloid leukemia.10
267012082016TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway.27
274860622016TLE4 regulation of wnt-mediated inflammation underlies its role as a tumor suppressor in myeloid leukemia.10
256310482015The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor.15
256310482015The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor.15
240997732013The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling.7
240997732013The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling.7
221692762012Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression.41
229274672012SUMOylated SoxE factors recruit Grg4 and function as transcriptional repressors in the neural crest.33
221692762012Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression.41

Citation

Dessen P

TLE4 (TLE family member 4, transcriptional corepressor)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56639/case-report-explorer/js/lib/popper.js